EFFECT OF MEBENDAZOLE ON GLUCOSE-UPTAKE OF ECHINOCOCCUS-GRANULOSUS CYSTS

Mice infected with secondary cysts of Echinococcus granulosus were treated ig with mebendazole (Meb) 25 mg . kg-1 . d-1 for 7-14 d. At 24 b after the last dose the endocysts in the treated mice were removed out for in vitro cultivation and exposed to ([U-C-14]glucose] 1.1 kBq . ml-1 for 2 min, no apparent difference in radioactivity content in the cyst walls between the treated and control groups was observed. When [U-C-14]glucose was given iv to the infected mice 24 h after they had been treated ig with Meb 25 mg . kg-1 or 50 mg . kg-1 daily for 14 d, the radioactivity content in the cyst wall and cyst fluid decreased significantly as compared to the corresponding control group. Nevertheless, no apparent change in the incorporation of radioactivity into the endogenous glycogen of the parasites was observed, although the glycogen in the cyst wall decreased markedly.