Cytokines and immunoglobulin-E in certain parasitic diseases.

Ninety Egyptian patients were classified into 7 groups, 6 with different parasitic infection and 10 normal controls. Forty patients with different schistosomiasis stages (1, 2 & 3) with compensated but the last one (stage 4) of decompansated schistosomiasis. Gs3 & 4 of mixed infections with schistosomiasis and HCV & HBV respectively. The last 3 patients groups were infected with toxoplasmosis, filariasis and hymenolepiasis nana. IL2, IL4 & Ig E levels were measured. The results showed significant increase in IL2 (P < 0.05), (P < 0.01), P < 0.01) & (P < 0.001) among stages (1, 2, 3 & 4) versus control respectively. In chronic schistosomiasis with HCV & HBV, significance was P = < 0.001 & P < 0.05 respectively, among toxoplasmosis, filariasis and hymenolepiasis patients, it was P = < 0.001, 0.05 & 0.01 respectively. The IL 4 level showed highly significant increase (P< 0.001) among stage 1, 2, Gs 2, 3 & 6. There was significant increase (P < 0.01) with stage 3 in Gs 4 & 5 but, without significance (P > 0.05) increased in decompensate schistosomiasis patients. IgE level and test of significance versus controls were given and results were discussed.