The synthesis of 10-(4-methylpiperazino)dibenzo (b,f)thiepin and related compounds. Neurotropic and psychotropic agents.

The preparation of 10-(4-methylpiperazino) dibenzo [b, f] thiepin (16a) and related Compounds is described. The reduction of 16a in an acidic medium yield the dihydro derivative (21) which was pharmacologically a valuable compound. Many of the compounds in this series showed marked neuroleptic effects similary to octoclotepine (2).