Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 Richard S Houlston , Jeremy Cheadle , Sara E Dobbins , Albert Tenesa , Angela M Jones , Kimberley Howarth , Sarah L Spain , Peter Broderick , Enric Domingo , Susan Farrington , James G D Prendergast , Alan M Pittman , Evi Theodoratou , Christopher G Smith , Bianca Olver , Axel Walther , Rebecca A Barnetson , Michael Churchman , Emma E M Jaeger , Steven Penegar , Ella Barclay , Lynn Martin , Maggie Gorman , Rachel Mager , Elaine Johnstone , Rachel Midgley , Iina Niittymäki , Sari Tuupanen , James Colley , Shelley Idziaszczyk , Huw J W Thomas , Anneke M Lucassen , D Gareth R Evans , Eamonn R Maher , Timothy Maughan , Antigone Dimas , Emmanouil Dermitzakis , Jean-Baptiste Cazier , Lauri A Aaltonen , Paul Pharoah , David J Kerr , Luis G Carvajal-Carmona , Harry Campbell , Malcolm G Dunlop , Ian P M Tomlinson NATURE GENETICS（2010）
摘要
Ian Tomlinson, Richard Houlston, Malcolm Dunlop and colleagues report results of a large genome-wide association study of colorectal cancer. They identify four new risk loci and suggest that many more loci of similar effect size are likely to exist.
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关键词
colorectal cancer, susceptibility loci, meta-analysis, genome-wide
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