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Stringent programming of DNA methylation in humans.

Hnin T Aung,Dion K Harrison,Ian Findlay,John S Mattick,Nicholas G Martin,Bernard J Carroll

TWIN RESEARCH AND HUMAN GENETICS（2010）

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Abstract
We describe a PCR-based method called Amplified Methylation Polymorphism (AMP) for scanning genomes for DNA methylation changes. AMP detects tissue-specific DNA methylation signatures often representing junctions between methylated and unmethylated DNA close to intronexon junctions and/or associated with CpG islands. Identical AMP profiles are detected for healthy, young, monozygotic twins.
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Key words
DNA methylation,methylation-sensitive PCR,tissue-specific,identical twins
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