Induction of Differentiation in Leukemic Cell Strains with Myelopeptide-4
Bulletin of Experimental Biology and Medicine(2005)
Abstract
We studied the capacity of myelopeptide-4 (regulatory peptide of the bone marrow origin) to induce terminal differentiation of HL-60 and K-562 leukemic cells. Myelopeptide-4 increased the expression of CD14 and CD38 differentiation antigens on the surface of HL-60 cells and of CD44 antigen on K-562 cells, induced the appearance of mature monocyte/macrophages in HL-60 culture and hemoglobin-producing cells in K-562 cell culture, and stimulated phagocytic activity of THP-1 leukemic cells. Myelopeptide-4 is an endogenous factor of cell differentiation, a prospective agent for anti-leukemic therapy.
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Key words
myeloblastic leukemia,erythroblastic leukemia,myelopeptide-4,differentiation
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