The comparative characteristics of the effect of continuous ischemia and ischemia with periodic reperfusions on the function and metabolic indices of the rabbit kidney]

Continuous 40-min ischemia and ischemia with reperfusion (10 min of ischemia and 10 min of reperfusion) induced by ligation of the vascular kidney crus were compared in experiments on 17 New Zealand rabbits. Both in continuous and interrupted (in period 4) ischemia resulted in the growth of pO2 cortical layer which is likely to be due to reduced oxygen utilization of the cells caused by metabolic and renal function disorders. Examination of lipid peroxidation activity determined similar activation of this process in both ischemic variants. In spite of the fact that both continuous and interrupted ischemias induced similar hyperoxygenation of the cortical substance and the same activation of lipid peroxidation, functional damage was less severe in experiments with interrupted ischemia.