Ovarian stimulation with a protocol using a low dose of GnRH agonist in patients with elevated basal FSH

This study compare the ovarian response of patients with high day 3 FSH (> 6,5 UI/L), treated with two protocols; a protocol with a low dose of GnRH agonist and a so called "long protocol" with GnRH agonist in a depot formula. The ovarian response with the agonist low dose was better with less ampules (37, 1 vs 46,6) and a shorter duration of stimulation (10,5 vs 12,4 days). The number of mature oocyte was higher (5,9 vs 4,5) as well as the number of good quality embryo (3,2 versus 2,3). The E2 levels on day 8 was also higher (1 065 vs 460 pg/ml). The cancellation rate was lower (14 % vs 26 %). The use of the low dose protocol gave a better ovarian response for patients with high day 3 FSH, Large randomized studies are needed to confirm these data.