Increased Microvascular Permeability In Early Stage Of Dextran Sulfate Sodium-Induced Colitis: Its Interaction With Lansoprazole Binding Sites
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION(2006)
摘要
To clarify the microvascular changes and the effector sites of lansoprazole during the formation of colitis, the dextran sulfate sodium (DSS)-induced colitis was induced by the oral administration for 3 and 7 days. The alteration of the microvascular permeability was estimated by the intraaortic infusion of FITC-dextran. The effector sites of H-3-lansoprazole were examined by the intraaortic infusion of the radiolabelled compound and the autoradiographic procedure of water-soluble compounds. As a result, marked increase of the microvascular permeability was detected three days after DSS treatment near the inflammatory cells in the tip portion of the colonic mucosa. H-3-lansoprazole in the control rat colon was localized in the goblet cells, while in DSS-treated rats, H-3-lansoprazole was accumulated in the cytoplasm of the mesenchymal cells, and most of them coincided with polymorphonuclear leucocytes and macrophages.
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关键词
dextran sulfate sodium, FITC-dextran, lansoprazole, autoradiography, colitis, neutrophil, macrophage
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