Structure-Activity Relationship of 5′-Substituted Fluoro-Neplanocin A Analogues as Potent Inhibitors of S -Adenosylhomocysteine Hydrolase

Moon Hyung Ryong,Lee Kang Man,Lee Joo Hyun,Lee Sang Kook,Park Seung Bin,Chun Moon Woo,Jeong Lak Shin

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2005）

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摘要

Four 5-substitutedfluoro-neplanocin A analogues 1a-d were designed and synthesized, and the inhibitory activity against SAH was in the following order: NH2 > SH > F, N-3, indicating a hydrogen bonding donor is essential for inhibitory activity.

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关键词

potent inhibitors,structure-activity,fluoro-neplanocin,s-adenosylhomocysteine

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