Chemistry of pseudomonic acid. Part 16. Aryl and heteroaryl ketone derivatives of monic acid.

Angela Abson,Nigel J P Broom,P A Coates,John S Elder,Andrew K Forrest,Peter C T Hannan,A J Hicks,Peter J Ohanlon,Nicky D Masson,Neil David Pearson,J E Pons,Jennifer M Wilson

JOURNAL OF ANTIBIOTICS（1996）

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摘要

The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl analogues.

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