鼠疫亚单位疫苗的免疫学效果评价

Qing-wen Zhang,Zhi-zhen Qi,You-quan Xin,Yong-hai Yang,Hai-lian Wu,Han-qing Yang,Jian-ping Feng,Xing Jin,Bai-zhong Cui,Tang Wang,Ben-chuan Wu,Ye-feng Qiu,Wang Wang,Zhao-biao Guo,Zu-yun Wang,Rui-fu Yang,Hu Wang,Xiao-yi Wang

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]（2009）

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Abstract

9.10,P<0.01),而豚鼠和兔产生的F1 IgG抗体滴度的差异无统计学意义(q=0.06,P=0.81).亚单位疫苗免疫的小鼠、豚鼠和兔免疫保护率分别为100%(10/10)、86%(12/14)和100%(5/5);EV76疫苗免疫的小鼠、豚鼠和兔免疫保护率分别为100%(6/6)、93%(13/14)和100%(6/6).结论 BALB/c小鼠是较好的评价鼠疫亚单位疫苗的小型动物;豚鼠评价鼠疫亚单位疫苗存在较大个体差异;兔也可用作评价鼠疫亚单位疫苗的动物.

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