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Effects of dopamine beta-hydroxylase genotype and disulfiram inhibition on catecholamine homeostasis in mice.

Brooke N Bourdélat-Parks,George M Anderson,Zoe R Donaldson,Jay M Weiss,Robert W Bonsall, Milburn S Emery,L Cameron Liles,David Weinshenker

Psychopharmacology（2005）

Cited 87|Views8
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Abstract
The data reveal potentially important and apparently additive effects of Dbh genotype and disulfiram administration on PFC catecholamine metabolism. These effects may have implications for genetic control of DBH activity in humans and for understanding therapeutic effects of disulfiram.
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Key words
knockout,mice,norepinephrine,dopamine,tyrosine hydroxylase,pharmacogenetic
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