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Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372.

Y Enomoto,K Shiomi,M Hayashi,R Masuma,T Kawakubo,K Tomosawa,Y Iwai,S Omura

JOURNAL OF ANTIBIOTICS（1996）

Cited 35|Views6
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Abstract
A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg-372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC50 value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 mu M, respectively.
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new platelet aggregation inhibitor,penicillium herquei
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