17 Beta-Estradiol Increases The Number Of Effector Memory Cd8(+) Lymphocytes In Mice With Contact Hypersensitivity And Among Cultured Splenocytes

To determine how estrogen exacerbates allergies, the effects of 17 beta-estradiol (E2) on lymphocyte proliferation were investigated. BALB/c mice were ovariectomized, administered 3.2 mu g E2, and sensitized with 50 mu L 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one. After 7 days, their spleens were excised and flow cytometrically analyzed. The CD8更多