Gastric Eicosanoid Synthesis In Normal Subjects And Alcoholics After Ethanol Stimulation

This work studied the effect of different ethanol concentrations on the eicosanoid accumulation in human gastric incubates of healthy volunteers and chronic alcoholics, determining the in vitro eicosanoid release both in the basal condition and after different ethanol concentrations, The basal release of PGE(2) and LTC(4) in alcoholics is higher than in healthy volunteers, Various alcohol concentrations cause an increase in LTC(4) and PGE(2) in healthy volunteers; we observed no LTC(4) increase in alcoholics and although PGE(2) levels increased after 20% ethanol, they remained constant at higher ethanol concentrations.