Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae).

Feras Q Alali,Ahmad A Gharaibeh,Abdullah Ghawanmeh,Khaled Tawaha,Amjad Qandil,Jason P Burgess,Arlene Sy,Yuka Nakanishi,David J Kroll,Nicholas H Oberlies

NATURAL PRODUCT RESEARCH（2010）

Cited 12|Views7

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Abstract

A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(-)-cornigerine (5), along with four known compounds, but new to the species: (-)-colchicine (1), (-)-demecolcine (2), (-)-N-methyl-(-)-demecolcine (3) and 3-demethyl-N-methyl-(-)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel.

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Key words

Colchicum crocifolium,colchicinoids,Jordan medicinal plants,colchicine

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