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Synthesis And Antileishmanial Activity Of Lipidic Amino Alcohols

Elaine S. Coimbra,Mauro V. De Almeida,Celso O. R. Junior,Aline F. Taveira,Cristiane F. Da Costa,Ana C. De Almeida,Elaine F. C. Reis,Adilson D. Da Silva

CHEMICAL BIOLOGY & DRUG DESIGN（2010）

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Abstract
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 mu m. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
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amino alcohols,antileishmanial activity,lipophilicity
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