Trka And P75(Ntr) In The Ovary Of Adult Cow And Pig
JOURNAL OF ANATOMY(2005)
摘要
Neurotrophins play a critical role in the development of the mammalian ovary, oogenesis and folliculogenesis. In this study we investigated the cell localization of the two main receptors for nerve growth factor (NGF), TrkA and p75(NTR), in the cow and pig ovary, using immunohistochemistry. Specific immunoreactivity for TrkA and p75(NTR) was detected in the ovary of both species, but the pattern and intensity of immunostaining were marginally different between them. The follicular cells regularly expressed immunoreactivity for both receptors. Immunoreactivity was also detected in the oocytes, independently of the maturational stage of the follicles, with the exception of primordial and primary follicles of the pig which did not display p75(NTR). Taken together, these results suggest a possible direct role of NGF on oocytes expressing TrkA and p75(NTR), in addition to the well-known roles in other ovary functions. The practical relevance of these data remains to be clarified.
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关键词
cow, neurotrophins, ovary, p75(NTR), pig, TrkA
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