ALDECALMYCIN, A NEW ANTIMICROBIAL ANTIBIOTIC FROM STREPTOMYCES .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
The Journal of antibiotics(1994)
Abstract
A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The H-1 and C-13 NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).
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Key words
streptomyces,new antimicrobial antibiotic,fermentation,physico-chemical
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