Optimizing Polymeric Nanoparticle Core Designs for Gene Delivery
Bioengineering Conference(2013)
摘要
Polymeric nanoparticles offer extraordinary promise as gene delivery vehicles, and recent advances in their designs have allowed for targeted deliveries with multi-stage releases of payloads. Despite these advances, delivery efficiency can still be improved. Namely, the core of a multilayered particle may be designed in such a way as to facilitate unloading once within the cell, with minimized electrostatic binding and waste of genes following endocytotic burst. Through creating a core particle that is semi-stable, further layers may functionally stabilize the polymeric complex until intracellular delivery is achieved, at which point the semistable configuration may promote payload release.
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关键词
biomedical materials,cellular biophysics,electrostatics,gene therapy,nanomedicine,nanoparticles,polymers,delivery efficiency,electrostatic binding,endocytotic burst,gene delivery,intracellular delivery,multilayered nanoparticles,polymeric complex,polymeric nanoparticle core designs,polymeric gene deliveries,cellular reprogramming,core nanoparticles,dna,plastics,payloads
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