Computational Study Of Particle Deposition In Patient Specific Geometries

Bioinformatics and Bioengineering(2013)

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Abstract
The present work focuses on the study of particle deposition in segments of the cardiovascular system. In particular, the geometry of an iliac bifurcation is reconstructed from medical imaging data and the flow fields of both blood and particles are obtained using Computational Fluid Particle Dynamics techniques. Particle convection, diffusion and inertia are taken into account in the simulations. The numerical experiments indicate that diffusion dominates deposition and only 10% of the injected particles deposit in the bifurcation. Both blood flow field and the characteristics of the patient specific geometry influence the particle deposition sites. Overall, the proposed methodology could become a useful tool for the design and optimization of biomedical applications.
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Key words
bifurcation,biological fluid dynamics,cardiovascular system,computational fluid dynamics,image reconstruction,medical image processing,biomedical applications,blood flow fields,cardiovascular system,computational fluid particle dynamics techniques,iliac bifurcation,medical imaging data,optimization,particle convection,particle deposition sites,particle flow fields,patient specific geometries
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