Microelectro Thermofluidic Packaging For Single Chip Integrated Viral Rna Extraction And Rt-Pcr Microdevices
2010 12TH ELECTRONICS PACKAGING TECHNOLOGY CONFERENCE (EPTC)(2010)
摘要
This paper presents a microelectrothermofluidic packaging of integrated microdevice for viral ribonucleic acid (RNA) extraction from blood samples and its amplification through a reverse transcription (RT)-polymerase chain reaction (PCR) method for application to the point-of-care (POC) infectious disease diagnostics. Integrated microdevice consists of solid phase extraction microchannel structure, microfluidic mixer, and meander-shaped microchamber for RT-PCR. Metallic microheater and resistive temperature detection (RTD) microsenosr is monolithically integrated with fluidic components. In order to secure both electrical and fluidic interconnections, spring-loaded electrical pin and drilled microchannel structure has been design in polycarbonate micropackaging structure. In the biotesting, we have demonstrated to detect dengue serotype III virus from the 80 mu l of blood sample with 80pfu virus concentration.
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关键词
integrated circuit interconnections,integrated circuit packaging,microfabrication,microfluidics,microorganisms,microsensors,RT-PCR microdevices,biotesting,electrical interconnections,fluidic interconnections,integrated microdevice,meander-shaped microchamber,metallic microheater,microelectrothermofluidic packaging,microfluidic mixer,point-of-care infectious disease diagnostics,polycarbonate micropackaging structure,resistive temperature detection microsensor,reverse transcription-polymerase chain reaction,single chip integrated viral RNA extraction,solid phase extraction microchannel structure,spring-loaded electrical pin,viral ribonucleic acid extraction,
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