Microelectro Thermofluidic Packaging For Single Chip Integrated Viral Rna Extraction And Rt-Pcr Microdevices

Tae Goo Kang,Hong Miao Ji,Siow Pin Melvin Tan,Guang Kai Ignatius Tay,Ming Yi Daniel Ang,Siti Rafeah Bte Mohamed Rafei,Kum Cheong Tang,Li Zhang,Xiaowu Zhang,Yu Chen

2010 12TH ELECTRONICS PACKAGING TECHNOLOGY CONFERENCE (EPTC)（2010）

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摘要

This paper presents a microelectrothermofluidic packaging of integrated microdevice for viral ribonucleic acid (RNA) extraction from blood samples and its amplification through a reverse transcription (RT)-polymerase chain reaction (PCR) method for application to the point-of-care (POC) infectious disease diagnostics. Integrated microdevice consists of solid phase extraction microchannel structure, microfluidic mixer, and meander-shaped microchamber for RT-PCR. Metallic microheater and resistive temperature detection (RTD) microsenosr is monolithically integrated with fluidic components. In order to secure both electrical and fluidic interconnections, spring-loaded electrical pin and drilled microchannel structure has been design in polycarbonate micropackaging structure. In the biotesting, we have demonstrated to detect dengue serotype III virus from the 80 mu l of blood sample with 80pfu virus concentration.

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关键词

integrated circuit interconnections,integrated circuit packaging,microfabrication,microfluidics,microorganisms,microsensors,RT-PCR microdevices,biotesting,electrical interconnections,fluidic interconnections,integrated microdevice,meander-shaped microchamber,metallic microheater,microelectrothermofluidic packaging,microfluidic mixer,point-of-care infectious disease diagnostics,polycarbonate micropackaging structure,resistive temperature detection microsensor,reverse transcription-polymerase chain reaction,single chip integrated viral RNA extraction,solid phase extraction microchannel structure,spring-loaded electrical pin,viral ribonucleic acid extraction,

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