The influence of molecular charges on microtubule curvatures in an electrical field
Solid-State Sensors, Actuators and Microsystems(2013)
Abstract
Toward a novel molecular separation, we propose a method to control gliding directions of microtubules (MTs) using a kinesin-MT system. The directions are controlled by electrical charges of cargo molecules partially labeled on the minus ends of MTs. We designed MTs labeled with streptavidin (SA), nanogold (NG), or dsDNA molecules, and evaluated their curvatures in an electrical field. The curvature of DNA-MT was larger than those of SA-MT or NG-MT because of DNA's large negative charge. These differences of curvatures enable to separate gliding MTs according to their cargo molecules.
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Key words
dna,biological techniques,gold,microfluidics,nanoparticles,nanotechnology,au,cargo molecule,dsdna molecule,electrical charge,electrical field,gliding direction,kinesin-mt system,microtubule curvature,molecular charge,molecular separation,nanogold molecule,negative charge,streptavidin molecule,microtubule,avidin-biotin bindings,charges,gliding assay,kinesin,trajectory,polymers,proteins,electric fields,fluorescence
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