Biomedical microdevice for analyzing the effect of electrochemotherapy on cancer cells

Younsuk Choi,Hongbae Kim,Seunghoon Kim,Jaekyu Choi,Jekyun Park

Denver, CO（2009）

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摘要

A microfabricated cell-based testing device for electrochemotherapy (ECT) which mimics a clinical electroporator of circular needle-array has been developed while keeping the similarity of electric field strength distribution. Until now, the performances between the electroporators of two- and six-needle circular array electrodes, which are general needle-type clinical electroporators for ECT, have not been evaluated systemically although these two configurations are the two basic invasive electrodes in ECT. In this study, the cell-based performances of two-types of electroporators were analyzed by using propidium iodide and bleomycin on the developed ECT testing device and their electroporaion characteristics were exploited.

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关键词

biomems,bioelectric phenomena,biomedical electrodes,cancer,cellular biophysics,microfabrication,needles,patient treatment,tumours,ect testing device,biomedical microdevice,cancer cell,electric field strength,electrochemotherapy,electroporator,needle circular array electrode,propidium iodide,bleomycin,breast cance cell,cancer therapy,electroporation,breast cancer,electrodes,geometry,electric field,electric fields,fluorescence,testing

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