A high-throughput biosensor for detection and quantification of protein induced DNA bending

Xirui Zhang,Philipp S Spuhler,M Selim Unlu,Laura Sola,Marcella Chiari

Optical MEMS and Nanophotonics（2011）

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摘要

The functions of genes depend on interactions with DNA-binding proteins. DNA bends or kinks upon specific binding with proteins. This biosensor measures binding-induced conformational changes of DNA in a high-throughput manner with sub-nanometer accuracy.

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关键词

dna,biosensors,genetics,molecular biophysics,molecular configurations,proteins,dna bending,dna binding protein,conformational change,gene function,high throughput biosensor,protein detection,protein quantification,high-throughput biosensor,sub-nanometer,high throughput

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