Coherence analysis over the latent period of epileptogenesis reveal that high-frequency communication is increased across hemispheres in an animal model of limbic epilepsy.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference（2006）
Abstract
A total of 32 microwire electrodes were implanted bilaterally into the hippocampus of Sprague-Dawley rats, which were then stimulated in the manner prescribed for the chronic limbic epilepsy model. After the initial seizure brought on by the stimulation, the animals were recorded at a high sampling rate (approximately 12 kHz) for the entire duration of the latent period. Coherence was calculated across channels in both stimulated (and later seizing) animals and non-stimulated (and thus non-seizing control) animals. Average coherence over time was greatest in intrahemispherical electrode pairs in both stimulated and non-stimulated animals. However, the 200-800 Hz band displays increased coherence interhemispherically and up to 200 Hz band displays decreased coherence interhemispherically: this occurs only in stimulated animals.
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Key words
limbic epilepsy,200 to 800 hz,microwire electrodes,hippocampus,sampling rate,neurophysiology,biomedical measurement,animal model,sprague-dawley rats,epileptogenesis,chronic limbic epilepsy model,brain,high-frequency communication,microelectrodes,stimulated animals,nonstimulated animals,latent period,coherence analysis,high frequency
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