Arteries engineered from vascular cells

Laura E Niklason,J Gao,William A Abbott,Karen K Hirschi,Stuart L Houser,Robert P Marini,Robert Langer

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint（1999）

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摘要

A tissue engineering approach was developed to produce arbitrary lengths of vascular graft material from smooth muscle and endothelial cells that were derived from a biopsy of vascular tissue. A “biomimetic” pulsatile perfusion system was developed which mimicked some of the physical forces experienced by native arteries in vivo. Tissue engineered arteries were also made from porcine vascular cells, and were implanted in miniature swine, with patency documented up to 24 days by digital angiography

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关键词

biomimetics,blood vessels,cellular biophysics,haemorheology,muscle,arbitrary lengths,biodegradable scaffolds,biomimetic pulsatile perfusion system,endothelial cells,implanted in miniature swine,porcine vascular cells,smooth muscle cells,tissue engineered arteries,tissue engineering approach,vascular graft material,vascular tissue biopsy,endothelial cell,pediatrics,biomedical engineering,sliding mode control,in vivo,stress,bioreactors,tissue engineering

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