Picosecond conformational transition of a cyclic peptide observed by infrared spectroscopy
european quantum electronics conference（2003）
Abstract
By visible-pump/infrared-probe spectroscopy, a cyclic octapeptide with a photoswitchable azobenzene based pseudo amino acid (AMPB) embedded in its backbone is investigated. The linear corresponding molecule is used as a reference. The AMPB molecule can be switched by light between a cis and trans conformation. NMR investigations on bcAMPB show an ensemble of a few structures for the cis state and a well defined one for the trans state. A visible pump pulse is used to start the conformational change by switching the AMPB from cis to trans. The probe pulse covers a range of 1600 cm-1 to 1750 cm-1 with a time resolution of 0.7 ps.
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Key words
bio-optics,biological nmr,high-speed optical techniques,infrared spectra,molecular biophysics,molecular configurations,proteins,0.7 ps,nmr,cis state,cis transformation,cyclic octapeptide,cyclic peptide,infrared spectroscopy,photoswitchable azobenzene,picosecond conformational transition,pseudoamino acid,trans conformation,trans state,visible pump pulse,visible-pump/infrared-probe spectroscopy,winches,frequency,infrared,amino acid,absorption
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