Deformable Image Registration And Intensity Correction Of Cardiac Perfusion Mri

Dynamic contrast Magnetic Resonance myocardial perfusion imaging has evolved into an accurate technique for the diagnosis of coronary artery disease. In this manuscript, we introduce and evaluate the performance of a non-rigid joint multi-level image registration and intensity correction algorithm on a common dataset. An objective functional is formed for which the corresponding Hessian and Jacobian is computed and employed in a multi-level Gauss-Newton minimization approach. In this paper, our experiments are based on elastic regularization on the transformation and total variation on the intensity correction. Our preliminary validations suggest that the registration scheme provides suitable motion correction if the parameters in the algorithm are properly tuned.