ProRank+ - A Method for Detecting Protein Complexes in Protein Interaction Networks.
BIOINFORMATICS 2014: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON BIOINFORMATICS MODELS, METHODS AND ALGORITHMS(2014)
Abstract
The course of developing effective medical treatments is typically based on the identification of disease-triggering protein complexes. In this paper, we present ProRank+, an effective method for detecting protein complexes in protein interaction networks. By assuming that complexes may overlap, the method uses a ranking algorithm to order proteins based on their importance in the network. In addition, a novel merging procedure is introduced to refine the predicted complexes in terms of their members. The experimental studies and results showed that ProRank+ outperforms several state-of-the-art methods in terms of the number of correctly-detected protein complexes using numerous quality measures.
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Key words
Google PageRank Algorithm,PPI,Protein Complex,Essential Protein,ProRank Algorithm
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