AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity against a murine melanoma pulmonary metastasis model in vivo.

Lingfei Han,Wei Wang,Jiahong Lu,Fanfei Kong,Ge Ma,Yiping Zhu,Dong Zhao,Jianlong Zhu,Wen Shuai,Qian Zhou,Ping Chen,Lei Ye,Jie Tao,Sarfraz Ahmad,Fang Li,Jing Sun

Cancer Letters（2014）

引用 14|浏览17

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摘要

•B16F1 cells can escape immune attack through the BTLA–HVEM inhibitory signal.•Blocking BTLA–HVEM pathway with sBTLA enhance antitumor immune response.•AAV–sBTLA plus HSP70 vaccine has therapeutic potential for metastatic melanoma.•The combination prophylactic vaccine promotes innate and adaptive immune response.

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关键词

BTLA,HSP70 vaccine,AAV,Immunotherapy,Metastatic melanoma

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