Do neutralising antibodies against exogenous interferon-beta inhibit endogenous signalling pathways?

Debra Fine,Abhishek Dattani,Isabel Moreira,Gavin Giovannoni,Monica Marta

Multiple Sclerosis and Related Disorders（2015）

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摘要

•NABs to exogenous IFNβ decrease treatment efficacy in multiple sclerosis.•NABs may interfere with anti-viral properties of endogenous IFNβ.•NABs usually appear within the first 2 years of therapy and should be screened for.

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关键词

BABs,IFNβ,IFNs,MRI,MS,MxA,NABs,PwMS,RR

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