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Orexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia

Elisa M. Fonseca,Mirela B. Dias,Kênia C. Bícego,Luciane H. Gargaglioni

Respiratory Physiology & Neurobiology（2016）

Cited 10|Views8
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Abstract
•Orexin neurons are located in the suprachiasmatic nucleus of toads.•Orexin acting on Orexin 1 receptors contributes to hypercarbic and hypoxic chemoreflexes.•Antagonism of orexin receptor 1 attenuates the CO2-drive to breath during dark phase.
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Key words
Hypocretin,Amphibian,CO2,Ventilation,Chemoreception
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