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Alterations of a spectrum of driver genes in female Chinese patients with advanced or metastatic squamous cell carcinoma of the lung

Zhao Qiong,Wang Yi Na,Wang Bo,Zeng Zhu,Peng Ling,Mou Hai Bo,Tang Ye Min,Zeng Lei, Hu Dan Na, Zhao Bo,Liu Jun Fang,Zheng Shu Seng

Lung Cancer（2015）

Cited 6|Views4
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Abstract
•We analyzed molecular abnormalities in Chinese females with advanced SQCLC.•Three specificities of female SQCLCs were observed: less smoking history, younger age and more peripheral type.•No significant differences in EGFR, KRAS, EML4-ALK, PTEN and FGFR1 between different genders were found.•Significant lower frequency of PIK3CA mutation was detected in females.
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Key words
Non-small cell lung cancer,Squamous cell carcinoma,Smoking,EGFR,PIK3CA,ALK
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