Activity of bone cement loaded with daptomycin alone or in combination with gentamicin or PEG600 against Staphylococcus epidermidis biofilms

Patricio Peñalba Arias,Ulrika Furustrand Tafin,Bertrand Bétrisey,Sebastian Vogt,Andrej Trampuz,Olivier Borens

Injury（2015）

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摘要

Daptomycin is a promising candidate for local treatment of bone infection due to its activity against multi-resistant staphylococci. We investigated the activity of antibiotic-loaded PMMA against Staphylococcus epidermidis biofilms using an ultra-sensitive method bacterial heat detection method (microcalorimetry).

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关键词

Bone cement,Daptomycin,Vancomycin,Gentamicin,Biofilm,S. epidermidis,Microcalorimetry,Infection,Arthroplasty,Two-stage exchange

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