LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).

Jan Bureš,Hana Jansová,Ján Stariat,Tomáš Filipský,Přemysl Mladěnka,Tomáš Šimůnek,Radim Kučera,Jiří Klimeš,Qin Wang,Katherine J Franz,Petra Kovaříková

Journal of Pharmaceutical and Biomedical Analysis（2015）

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Abstract

•Salicylaldehyde isonicotinoyl hydrazone (SIH) is an effective cytoprotective agent.•Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) is activated to SIH.•LC–UV/MS methods were developed and validated for analysis of SIH and BSIH.•BSIH activation was studied in vitro using LC–UV.•LC–MS method was used in an in vitro stability experiment and pilot in vivo study.

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Key words

Aroylhydrazone,Boronyl salicylaldehyde isonicotinoyl hydrazone,Prochelator salicylaldehyde isonicotinoyl hydrazone,Pharmacokinetics,Stability

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