The ratio of absolute lymphocyte count at interim of therapy to absolute lymphocyte count at diagnosis predicts survival in childhood B-lineage acute lymphoblastic leukemia.
Leukemia Research（2015）
Abstract
•We analyzed the impact of ALC-22/ALC-0 ratio on survival in 119 pediatric B-ALL patients.•ALC-22/ALC-0 ratio <10% was associated with inferior 5-year OS and EFS.•ALC-22/ALC-0 ratio reflected the host immunity and bone marrow recovery.•ALC was mainly associated with CD3+ T cells.•ALC-22/ALC-0 ratio is a novel, simple and effective biomarker to predict survival.
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Key words
Childhood,Acute lymphoblastic leukemia,Absolute lymphocyte count,Ratio,Lymphocyte subsets,Prognosis
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