A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer Roland Rad , Lena Rad , Wei Wang , Alexander Strong , Hannes Ponstingl , Iraad F Bronner , Matthew Mayho , Katja Steiger , Julia Weber , Maren Hieber , Christian Veltkamp , Stefan Eser , Ulf Geumann , Rupert Öllinger , Magdalena Zukowska , Maxim Barenboim , Roman Maresch , Juan Cadiñanos , Mathias Friedrich , Ignacio Varela , Fernando Constantino-Casas , Aaron Sarver , Jelle ten Hoeve , Haydn Prosser , Barbara Seidler , Judith Bauer , Mathias Heikenwälder , Emmanouil Metzakopian , Anne Krug , Ursula Ehmer , Günter Schneider , Thomas Knösel , Petra Rümmele , Daniela Aust , Robert Grützmann , Christian Pilarsky , Zemin Ning , Lodewyk Wessels , Roland M Schmid , Michael A Quail , George Vassiliou , Irene Esposito , Pentao Liu , Dieter Saur , Allan Bradley NATURE GENETICS（2014）
摘要
Roland Rad and colleagues report development of a new conditional piggyBac transposition system for performing insertional mutagenesis screens in mice. They apply the system to identify new oncogenic driver pathways for pancreatic cancer.
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关键词
pancreatic cancer, conditional piggybac transposition system, oncogenic networks, genetic screening
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