Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ

Giorgos Gouridis,Gea K Schuurman-Wolters,Evelyn Ploetz,Florence Husada,Ruslan Vietrov,Marijn de Boer,Thorben Cordes,Bert Poolman

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2014）

Cited 102|Views6

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Abstract

Bacterial ABC importer GlnPQ has two fused substrate-binding domains (SBDs). Single-molecule FRET is now used to probe the conformational dynamics of the SBDs, which are shown to directly influence transport rates.

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nature structural and molecular biology, science

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