MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity.

Archives of Biochemistry and Biophysics（2014）

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摘要

•MAGE-A3 regulates genes via zinc finger transcription factor (ZNF) KRAB domains.•MAGE-A3 enhances gene repression by ZNF KRAB domains with A or A+b box motifs.•MAGE-A3 de-represses genes by ZNF KRAB domains with A+B box motifs.•MAGE-A3 does not affect gene regulation by ZNFs with KRAB Scan motifs.•MAGE-A3 gene regulation depends on the structure of ZNF KRAB domains.

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关键词

Melanoma,KRAB,ZNF,MAGE

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