c-Cbl regulates αPix-mediated cell migration and invasion.

Min Woo Seong,Ji Ho Park,Hee Min Yoo,Seung Wook Yang,Kyu Hee Oh,Seung Hyeun Ka,Dong Eun Park,Soon-Tae Lee,Chin Ha Chung

Biochemical and Biophysical Research Communications（2014）

引用 15|浏览18

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摘要

•c-Cbl ubiquitinates αPix for proteasome-mediated degradation.•C6 and A172 glioma cells lack c-Cbl, which leads to stabilization of αPix.•The accumulated αPix promotes migration and invasion of the cancer cells.•The lack of c-Cbl in the cells appears responsible for their malignant behavior.

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关键词

αPix,c-Cbl,Cell migration,Cell invasion,Glioma

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