Micronucleus induction in rat liver and bone marrow by acute vs. repeat doses of the genotoxic hepatocarcinogen monocrotaline.

Takashima Rie,Takasawa Hironao,Wako Yumi,Yasunaga Katsuaki,Hattori Akiko,Kawabata Masayoshi,Nakadate Kiyoko,Nakagawa Munehiro,Hamada Shuichi

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

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摘要

•Monocrotaline induced micronuclei with repeated dose in the liver, but not in the bone marrow.•Liver micronucleus assay might be appropriate for the repeated dose regimen.•A repeated dose liver micronucleus (RDLMN) assay was evaluated for its effectiveness.

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关键词

Micronucleus assay,Repeated-dose liver genotoxicity assay,Genotoxic hepatocarcinogens,Monocrotaline

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