Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase.
Biochemical and Biophysical Research Communications（2015）
Abstract
•Oridonin is an anticancer drug isolated from Traditional Chinese Medicine.•Oridonin increases Bim expression and decreases FAS expression in uveal melanoma cells.•Oridonin activates apoptosis signaling in uveal melanoma cells.•Oridonin displays potent anticancer activity in uveal melanoma cells.
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Key words
Oridonin,Uveal melanoma,Apoptosis,Bim,Fatty Acid Synthase
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