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Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.

John Skidmore,Jag Heer,Christopher N Johnson, David Norton,Sally Redshaw,Jennifer Sweeting,David Hurst,Andrew Cridland,David Vesey,Ian Wall,Mahmood Ahmed,Dean Rivers,James Myatt,Gerard Giblin,Karen Philpott,Umesh Kumar,Alexander Stevens,Rino A Bit,Andrea Haynes,Simon Taylor,Robert Watson,Jason Witherington,Emmanuel Demont,Tom D Heightman

JOURNAL OF MEDICINAL CHEMISTRY（2014）

引用 19|浏览44
关键词
receptor,pharmacokinetic,zwitterionic chemotypes,pharmacodynamic profiles
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