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Cross-talks between c-Kit and PKC isoforms in HMC-1(560) and HMC-1(560,816) cells. Different role of PKCδ in each cellular line.

Araceli Tobío,Amparo Alfonso,Luis M Botana

Cellular Immunology（2015）

Cited 7|Views2
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Abstract
•STI571 activates PKCδ isoform resulting in HMC-1560 apoptosis.•c-kit inhibition implies nuclear PKCδ translocation.•STI571 mechanism of action is PKCδ-dependent.•PKCδ activity is required to obtain an optimal STI571 treatment efficiency.
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Key words
HMC-1,PKC,c-kit,STI571,PMA
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