Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease.

Fernando Goñi,Candace K Mathiason,Lucia Yim,Kinlung Wong,Jeanette Hayes-Klug,Amy Nalls,Daniel Peyser,Veronica Estevez,Nathaniel Denkers,Jinfeng Xu,David A Osborn,Karl V Miller,Robert J Warren,David R Brown,Jose A Chabalgoity,Edward A Hoover,Thomas Wisniewski

Vaccine（2015）

引用 54|浏览16

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摘要

Illustrates the study design of the CWD vaccination experiment. There were five vaccinated white-tailed deer and 6 vehicle controls. Deer were matched for Prnp genotype (95Q/96G/116A/138S/226Q), except two deer in both the control and vaccinated group had the most common polymorphism (∼26% of deer) that confers partial resistance to CWD infection, codon 96 G/S instead of 96 G/G.

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关键词

Prion protein,Immunization,Salmonella vaccine strain,Bovine spongiform encephalopathy,Chronic wasting disease,White-tailed deer,Mucosal vaccination

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