Simultaneous impedance spectroscopy and stimulation of human iPS-derived cardiac 3D spheroids in hanging-drop networks

Sebastian C Burgel,Yannick Schmid,Irina Agarkova,David A Fluri,Jens M Kelm,Andreas Hierlemann,Olivier Frey

Micro Electro Mechanical Systems（2015）

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摘要

Here, we present electrical impedance spectroscopy (EIS) data of human iPS-derived cardiac 3D spheroids with electric stimulation integrated in a hanging drop network. Microscopy videos of the beating spheroids were correlated with synchronously obtained EIS recordings. For stimulation, the spheroid was exposed to a continuous sinusoidal electric field - in contrast to traditional pulse trains. This stimulating field was supplied via the same electrodes that were used for the EIS recordings. Our measurements revealed a beating frequency modulation upon tuning the stimulation signal amplitude.

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关键词

bioelectric phenomena,biomedical electrodes,biomedical measurement,biomedical optical imaging,cardiology,electric impedance imaging,electric impedance measurement,medical image processing,optical microscopy,video signal processing,eis recordings,electric stimulation,electrical impedance spectroscopy,frequency modulation,hanging-drop networks,human ips-derived cardiac 3d spheroids,microscopy videos,sinusoidal electric field,stimulation signal amplitude,optical imaging,optical pumping,microscopy,impedance

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