Beat-by-beat Quantification of Cardiac Cycle Events Detected from Three-Dimensional Precordial Acceleration Signals.

The vibrations produced by the cardiovascular system that are coupled to the precordium can be noninvasively detected using accelerometers. This technique is called seismocardiography. Although clinical applications have been proposed for seismocardiography, the physiology underlying the signal is still not clear. The relationship of seismocardiograms of on the back-to-front axis and cardiac events is fairly well known. However, the three-dimensional6 vibrations detectable with modern accelerometers have not been quantified in terms of cardiac cycle events. A major reason for this might be the degree of inter-subject variability observed in three-dimensional seismocardiograms. We present a method to quantify threedimensional seismocardiography in terms of cardiac cycle events. First, cardiac cycle events are identified from the seismocardiograms and then assigned a number based on the location in which the corresponding event was found. 396 cardiac cycle events from 9 healthy subjects and 120 cardiac cycle events from patients suffering from atrial flutter were analyzed. Despite the weak inter-subject correlation of the waveforms (0.05, 0.27, and 0.15 for the x, y, and z axes, respectively), the present method managed to find latent similarities in the seismocardiograms of healthy subjects. We observed that in healthy subjects the distribution of cardiac cycle event coordinates was centered on specific locations. These locations were different in patients with atrial flutter. The results suggest that spatial distribution of seismocardiographic cardiac cycle events might be used to discriminate healthy individuals and those with a failing heart.