Amyloid β oligomer-induced ERK1/2-dependent serine 636/639 phosphorylation of insulin receptor substrate-1 impairs insulin signaling and glycogen storage in human astrocytes.

•Aβ1–42 oligomers inhibit serine phosphorylation of Akt at 473 and GSK3β at serine 9.•Aβ1–42 oligomers increase GSK3β phosphorylation at tyrosine 216.•Phosphorylation of IRS-1 at serine 636/639 is induced by Aβ1–42 oligomers.•ERK1/2 phosphorylation is increased after Aβ1–42 oligomer treatment.•Effects of Aβ1–42 oligomers on insulin signaling are partially reversed by PD98059.